My career pathway started with a first Ph.D. degree in Applied Biosciences from Sardar Patel University VallabhVidya Nagar, India, followed by a second Ph.D. degree in Medicine from University of Miyazaki, Miyazaki, Japan. In my startup career as scientist in Shri Murugappa Chettiar Research center, Chennai, India, we demonstrated India’s first community Spirulina unit and subsequently expanded to major Spirulina producing industries in India. Later on further postdoctoral years in biology at Miyazaki University and culminating in a faculty position in Applied Physiology at the University of Miyazaki. Our current interests include the generation of novel platforms for delivery of therapeutics of nano-sized biomaterials payloads into specific cell types and the utilization of this model as new drug discovery and validation of new drug for wound healing. Aberrant overexpression of pro-inflammatory molecules is believed to be a key mediator in the formation of chronic skin wounds, and the inhibition of these signals may be an effective therapeutic strategy to promote healing. As a nutraceuetical-biomaterial, we studied C-Phycocyanin, Curcumin, Vinofelon, emodin has been widely used in wound healing, cell migration controlling agent, and other biomedical applications. Materials can be formulated in a variety of forms, such as powder, film, sphere, gel, and fiber. These features make nutraceutical an almost ideal biomaterial in cell culture applications, and cell cultures arguably constitute the most practical way to evaluate bio-compatibility and bio-toxicity of nutraceutical. The advantages of cell cultures are that they can be performed under totally controlled environments, allow high throughput functional screening, and are less costly, as compared to other assessment methods. Our aim is to update the current status of how bio-nanoparticles can be utilized to accelerate the dermal wound healing. Another area of current research we are doing in our group is to reveal the mechanism of miRNA mediated wound healing. MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of gene expression, and have displayed important roles in areas spanning from embryonic development to skin physiology. Our studies proved that there is dysregulation of miRNA-21 in normal and diabetic wound healing. Curently we are focusing on the mechanism of dysregulated miRNA-21 during the wound healing. With existing technologies of nucleic acid transfer and miRNA modulation, it is anticipated that once the roles of miRNA-21 in wound healing have been clarified, there will be a vast new vista of opportunities brought up for development of miRNA-targeted therapies for wound care. Recently we also started work on arsenic induced skin carcinogenesis with special emphasis on signatory microRNA.

Mechanism of miRNA mediated wound healing, skin carcinogenesis with special emphasis on signatory microRNA.