Radiology & Radiological Sciences
Johns Hopkins University
Shanmugasundaram Ganapathy-Kanniappan obtained his Ph.D degree from the University of Madras and underwent postdoctoral training at premier institutes such as National Institute of Immunology (NII), New Delhi, University of California at Los Angeles (UCLA) and Johns Hopkins University. Currently, Dr. Ganapathy-Kanniappan is an Assistant Professor in the Department of Radiology & Radiological Science of Johns Hopkins University School of Medicine. Dr. Ganapathy-Kanniappan's research interest includes cancer metabolism and altered energy metabolism in liver fibrosis. Dr. Ganapathy-Kanniappan obtained his Ph.D degree from the University of Madras and underwent postdoctoral training at premier institutes such as National Institute of Immunology (NII), New Delhi and the University of California at Los Angeles (UCLA). After a fellowship in the Department of Medicine/ Hematology division at Johns Hopkins, he joined the Radiology department as a faculty. Dr. Ganapathy-Kanniappan has several publications in reputed journals and has written many reviews and a book chapter on cancer metabolism and therapeutic opportunities.
My primary research interest is to develop effective strategies that can selectively target “altered energy producing pathways” or “metabolic reprogramming” in disease conditions such as cancer and liver fibrosis. Liver cancer: Our aim is to develop an effective antiglycolytic strategy that can selectively and specifically disrupt tumor metabolism and improve the therapeutic outcome of HCC patients. Liver fibrosis: The long term goal is to develop effective therapeutic strategies for liver diseases such as fibrosis/cirrhosis by selective targeting of “energy metabolism” in hepatic stellate cells (HSCs) that exhibit uncontrolled activation. Breast cancer: Our goal is to revolutionize treatment regimens by replacing interventions that are challenged by lack of efficacy or increased toxicity”. With my background in cancer metabolism and collaboration with Drs. Bhujwalla and Dr.Wu, we intend to develop a novel framework whereby cancer metabolism could be minimally perturbed to trigger host immune response.
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