Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, Sweden. Tel: +4670978581; E mail: Sten.Friberg@ki.se
Citation: Friberg S (2016) Nanomedicine: Will It Be Able To Overcome Multidrug Resistance In Cancers? J Nanotec Nanosci 2: 100118
Copyrights: Â© 2016 Friberg S.
At present, every third individual in the Western world is diagnosed with a cancer at some point in their lives. In spite of great advances in oncology in recent decades, around 50% of these individuals will die from their diseases. The great majority of these deaths are caused by cancer cells endowed with multiple drug resistance (MDR). These cells are not eliminated by present-day therapies, and new strategies for general oncologic treatment are needed. The shape of such new treatments is emerging, and such treatments will likely be highly individualized, but at the same time highly complex and costly.
Keywords: Cancer, multiple drug resistance, multimodal therapy, malignant stem cells, nanotechnology.
Multimodality is mandatory, and the treatment steps will be sequential.
The plausible major steps are likely to be:
For these five steps, the medical profession is already in possession of most of the needed therapeutic agents. However, some of these agents are toxic when given intravenously in humans, and some of them are inactivated during the transport in the blood. Nanoparticles might offer a dual benefit by protecting the patient from the agent, and simultaneously protecting the agent from the patient.
What is lacking is knowledge of the time needed for each step and of the potential side effects for each step.
Effective targeting methods currently exist for superficial tumors (both primary and secondary), but not for deep-seated cancers .
Friberg S, Nystrom AM (2016) Nanomedicine: will it offer possibilities to overcome multiple drug resistance in cancer? J NANOBIOTECHNOLOGY 14: 17.